Cerebral Melanoma Metastases: A Critical Review on Diagnostic Methods and Therapeutic Options

Table 1

List of available diagnostic methods, their specific utility and Results which suggeest CNS melanoma metastasis.

Diagnostic methods	Suggestive result	Specific utility
Computed tomography	Hyperdense lesion	Primary exam
Magnectic resonance Images	Hyperintense lesion on T1 and hypointense lesion on T2-weighted images	More detailed exam
Optical coherence tomography	Increased optical backscatter	Intraoperatory exam
Positron emission tomography	High captation of compound 18F-10B-LBPA	Noninvasive radiation dose planning
Cintilography	Increased uptake of iofetamine	High sensible method
Immunohistochemistry	Finding of intermediate filament keratin	Differentiating between metastatic melanomas and primary central nervous system tumors
Monoclonal antibody	Raise of fibronectin, beta 2-microglobulin	Diagnosis of metastatic meningeal melanomatosis
Immunocytology	IgM and IgG index, IL-6 and TNF-alpha	Diagnosis of metastatic meningeal melanomatosis
Transcriptase-polymerase chain reaction (PCR)	Detection of melanoma-associated markers (MAGE-3, MART-1, and tyrosinase)	Diagnosis of subclinical CNS metastases