Table of Contents
ISRN Orthopedics
Volume 2011, Article ID 290851, 8 pages
Review Article

Antibiotic-Loaded Cement in Orthopedic Surgery: A Review

1Department of Orthopedics and Traumatology, AO CTO Hospital, Turin, Italy
2c/o AO CTO/M. Adelaide, Via Zuretti 29, 10126 Torino, Italy
3University of the Studies of Turin, Turin, Italy
4Materials Science and Chemical Engineering Department, Polytechnic of Turin, Duca degli Abruzzi, 24-10129 Turin, Italy
5Department of Clinical and Biological Sciences, c/o S. Luigi Hospital, Regione Gonzole, 10-10043 Orbassano, Italy

Received 9 May 2011; Accepted 27 May 2011

Academic Editors: J. Gallo, M. Hasegawa, and G. Papachristou

Copyright © 2011 Alessandro Bistolfi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Infections in orthopaedic surgery are a serious issue. Antibiotic-loaded bone cement was developed for the treatment of infected joint arthroplasties and for prophylaxes in total joint replacement in selected cases. Despite the widespread use of the antibiotic-loaded bone cement in orthopedics, many issues are still unclear or controversial: bacterial adhesion and antibiotic resistance, modification of mechanical properties which follows the addition of the antibiotic, factors influencing the release of the antibiotic from the cement and the role of the surface, the method for mixing the cement and the antibiotic, the choice and the effectiveness of the antibiotic, the combination of two or more antibiotics, and the toxicity. This review discusses all these topics, focusing on properties, merits, and defects of the antibiotic loaded cement. The final objective is to provide the orthopaedic surgeons clear and concise information for the correct choice of cement in their clinical practice.