Table of Contents
ISRN Hematology
Volume 2011, Article ID 294628, 5 pages
http://dx.doi.org/10.5402/2011/294628
Clinical Study

Management of Warfarin Anticoagulation in Patients with Fractured Neck of Femur

1Queen Alexandra Hospital, Portsmouth, UK
2Northern General Hospital, Sheffield, UK
3Colchester General Hospital, Colchester, UK
4Great Western Hospital, Swindon, UK

Received 11 October 2010; Accepted 5 December 2010

Academic Editors: R. M. Camire, M. Morfini, M. Sugimoto, and B. Wachowicz

Copyright © 2011 Feras Ashouri et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Marzolini and H. A. Wynne, “Should patients manage their own oral anticoagulation therapy?” Reviews in Clinical Gerontology, vol. 12, no. 4, pp. 275–281, 2003. View at Publisher · View at Google Scholar
  2. M. Sudlow, R. Thomson, B. Thwaites, H. Rodgers, and R. A. Kenny, “Prevalence of atrial fibrillation and eligibility for anticoagulants in the community,” The Lancet, vol. 352, no. 9135, pp. 1167–1171, 1998. View at Publisher · View at Google Scholar · View at Scopus
  3. M. Klein and G. J. Velan, “The timing of surgery for hip fracture: the case for early repair,” Israel Medical Association Journal, vol. 8, no. 9, p. 661, 2006. View at Google Scholar · View at Scopus
  4. C. G. Moran, R. T. Wenn, M. Sikand, and A. M. Taylor, “Early mortality after hip fracture: is delay before surgery important?” Journal of Bone and Joint Surgery. American, vol. 87, no. 3, pp. 483–489, 2005. View at Publisher · View at Google Scholar · View at Scopus
  5. J. V. Perez, D. J. Warwick, C. P. Case, and G. C. Bannister, “Death after proximal femoral fracture: an autopsy study,” Injury, vol. 26, no. 4, pp. 237–240, 1995. View at Publisher · View at Google Scholar · View at Scopus
  6. Scottish Intercollegiate Guidelines Network (SIGN), “Prevention and management of hip fracture in older people; a national clinical guideline,” SIGN Publication 56, Royal College of Physicians, Edinburgh, UK, 2002. View at Google Scholar
  7. T. Shiga, Z. Wajima, and Y. Ohe, “Is operative delay associated with increased mortality of hip fracture patients? Systematic review, meta-analysis, and meta-regression,” Canadian Journal of Anesthesia, vol. 55, no. 3, pp. 146–154, 2008. View at Google Scholar · View at Scopus
  8. P. Sircar, D. Godkar, S. Mahgerefteh, K. Chambers, S. Niranjan, and R. Cucco, “Morbidity and mortality among patients with hip fractures surgically repaired within and after 48 hours,” American Journal of Therapeutics, vol. 14, no. 6, pp. 508–513, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. P. Tharmarajah, J. Pusey, D. Keeling, and K. Willett, “Efficacy of warfarin reversal in orthopedic trauma surgery patients,” Journal of Orthopaedic Trauma, vol. 21, no. 1, pp. 26–30, 2007. View at Publisher · View at Google Scholar · View at Scopus
  10. O. E. Dahl, T. E. Gudmundsen, and L. Haukeland, “Late occurring clinical deep vein thrombosis in joint-operated patients,” Acta Orthopaedica Scandinavica, vol. 71, no. 1, pp. 47–50, 2000. View at Google Scholar · View at Scopus
  11. S. P. Frostick, “Death after joint replacement,” Haemostasis, vol. 30, no. 2, pp. 84–87, 2000. View at Google Scholar · View at Scopus
  12. A. S. Gallus, R. I. Baker, B. H. Chong, P. A. Ockelford, and A. M. Street, “Consensus guidelines for warfarin therapy: recommendations from the Australasian society of thrombosis and haemostasis,” Medical Journal of Australia, vol. 172, no. 12, pp. 600–605, 2000. View at Google Scholar · View at Scopus
  13. M. Al-Rashid and M. J. Parker, “Anticoagulation management in hip fracture patients on warfarin,” Injury, vol. 36, no. 11, pp. 1311–1315, 2005. View at Publisher · View at Google Scholar
  14. R. Bansal and D. K. Watson, “Surgical delay in acute admissions on warfarin: are we doing enough?” International Journal of Clinical Practice, vol. 59, no. 11, pp. 1283–1288, 2005. View at Publisher · View at Google Scholar · View at Scopus
  15. R. H. White, T. McKittrick, R. Hutchinson, and J. Twitchell, “Temporary discontinuation of warfarin therapy: changes in the international normalized ratio,” Annals of Internal Medicine, vol. 122, no. 1, pp. 40–42, 1995. View at Google Scholar · View at Scopus
  16. I. Starks, S. Cooke, C. Docker, and A. Raine, “Warfarinized patients with proximal femoral fractures: survey of UK clinical practice,” European Journal of Trauma and Emergency Surgery, vol. 35, no. 3, pp. 287–290, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. R. Verma, E. Tayton, and B. Birch, “Does oral vitamin K given in A&E help expedite surgery in fracture neck of femur patients on warfarin for atrial fibrillation?” Injury Extra, vol. 39, no. 5, pp. 177–178, 2008. View at Publisher · View at Google Scholar
  18. R. Laliberté, S. Chakrabarti, and J. Brodeur, “The influence of fasting and stress on the response of rats to warfarin,” Journal of Pharmacology and Experimental Therapeutics, vol. 196, no. 1, pp. 194–203, 1976. View at Google Scholar · View at Scopus
  19. G. J. Despotis, K. S. Filos, T. N. Zoys, C. W. Hogue Jr., E. Spitznagel, and D. G. Lappas, “Factors associated with excessive postoperative blood loss and hemostatic transfusion requirements: a multivariate analysis in cardiac surgical patients,” Anesthesia and Analgesia, vol. 82, no. 1, pp. 13–21, 1996. View at Publisher · View at Google Scholar · View at Scopus
  20. C. S. Landefeld, E. F. Cook, M. Flatley, M. Weisberg, and L. Goldman, “Identification and preliminary validation of predictors of major bleeding in hospitalized patients starting anticoagulant therapy,” American Journal of Medicine, vol. 82, no. 4, pp. 703–713, 1987. View at Google Scholar · View at Scopus
  21. S. Travis, R. Wray, and K. Harrison, “Perioperative anticoagulant control,” British Journal of Surgery, vol. 76, no. 11, pp. 1107–1108, 1989. View at Google Scholar · View at Scopus
  22. T. P. Baglin, D. M. Keeling, and H. G. Watson, “Guidelines on oral anticoagulation (warfarin): third edition—2005 update,” British Journal of Haematology, vol. 132, no. 3, pp. 277–285, 2006. View at Publisher · View at Google Scholar · View at Scopus
  23. A. K. Jaffer, D. J. Brotman, and N. Chukwumerije, “When patients on warfarin need surgery,” Cleveland Clinic Journal of Medicine, vol. 70, no. 11, pp. 973–984, 2003. View at Google Scholar · View at Scopus
  24. J. Spandorfer, “The management of anticoagulation before and after procedures,” Medical Clinics of North America, vol. 85, no. 5, pp. 1109–1116, 2001. View at Publisher · View at Google Scholar · View at Scopus
  25. J. M. Hynson, J. A. Katz, and H. U. Bueff, “Epidural hematoma associated with enoxaparin,” Anesthesia and Analgesia, vol. 82, no. 5, pp. 1072–1075, 1996. View at Publisher · View at Google Scholar · View at Scopus
  26. W. R. Porterfield and C. L. Wu, “Epidural hematoma in an ambulatory surgical patient,” Journal of Clinical Anesthesia, vol. 9, no. 1, pp. 74–77, 1997. View at Publisher · View at Google Scholar · View at Scopus
  27. E. P. Vandermeulen, H. Van Aken, and J. Vermylen, “Anticoagulants and spinal-epidural anesthesia,” Anesthesia and Analgesia, vol. 79, no. 6, pp. 1165–1177, 1994. View at Google Scholar · View at Scopus
  28. J. D. Douketis, “Perioperative anticoagulation management in patients who are receiving oral anticoagulant therapy: a practical guide for clinicians,” Thrombosis Research, vol. 108, no. 1, pp. 3–13, 2002. View at Publisher · View at Google Scholar · View at Scopus
  29. M. Baker and A. J. Ollivere, “Low-dose oral vitamin K is a safe and effective method for controlled anticoagulation reversal in orthopaedic trauma patients,” Injury Extra, vol. 39, no. 5, pp. 198–198, 2008. View at Google Scholar
  30. A. Brooksbank, S. Sckhtivel, and P. Rickhuss, “The incidence and management of hip fracture patients admitted on warfarin, a prospective study,” The Journal of Bone and Joint Surgery. British, vol. 86, p. 233, 2004. View at Google Scholar
  31. M. J. Kirsch, G. A. Vrabec, R. A. Marley, A. E. Salvator, and F. F. Muakkassa, “Preinjury warfarin and geriatric orthopedic trauma patients: a case-matched study,” Journal of Trauma-Injury, Infection and Critical Care, vol. 57, no. 6, pp. 1230–1233, 2004. View at Publisher · View at Google Scholar · View at Scopus
  32. P. Baker, A. Gleghorn, T. Tripp, K. Paddon, H. Eagleton, and D. Keeling, “Reversal of asymptomatic over-anticoagulation by orally administered vitamin K,” British Journal of Haematology, vol. 133, no. 3, pp. 331–336, 2006. View at Publisher · View at Google Scholar
  33. T. Hanslik and J. Prinseau, “The use of vitamin K in patients on anticoagulant therapy: a practical guide,” American Journal of Cardiovascular Drugs, vol. 4, no. 1, pp. 43–55, 2004. View at Publisher · View at Google Scholar · View at Scopus
  34. J. Ansell, J. Hirsh, E. Hylek, A. Jacobson, M. Crowther, and G. Palareti, “Pharmacology and management of the vitamin K antagonists: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition),” Chest, vol. 133, no. 6, pp. 160S–198S, 2008. View at Publisher · View at Google Scholar · View at Scopus
  35. J. H. Levy, K. A. Tanaka, and W. Dietrich, “Perioperative hemostatic management of patients treated with vitamin K antagonists,” Anesthesiology, vol. 109, no. 5, pp. 918–926, 2008. View at Publisher · View at Google Scholar · View at Scopus
  36. “Haemostasis and Thrombosis Task Force for the British Committee for Standards in Haematology. Guidelines on oral anticoagulation: third edition,” British Journal of Haematology, vol. 101, pp. 374–387, 1998.
  37. J. P. Hanley, “Warfarin reversal,” Journal of Clinical Pathology, vol. 57, no. 11, pp. 1132–1139, 2004. View at Publisher · View at Google Scholar · View at Scopus
  38. M. Makris and H. G. Watson, “The management of coumarin-induced over-anticoagulation,” British Journal of Haematology, vol. 114, no. 2, pp. 271–280, 2001. View at Publisher · View at Google Scholar
  39. J. Ansell, J. Hirsh, J. Dalen et al., “Managing oral anticoagulant therapy,” Chest, vol. 119, no. 1, pp. 22S–38S, 2001. View at Google Scholar · View at Scopus
  40. R. O. Bonow, B. Carabello, A. C. de Leon Jr. et al., “Guidelines for the management of patients with valvular heart disease: executive summary: a report of the American College of Cardiology/American Heart Association task force on practice guidelines (Committee on Management of Patients With Valvular Heart Disease),” Circulation, vol. 98, no. 18, pp. 1949–1984, 1998. View at Google Scholar
  41. J. A. Heit, “Perioperative management of the chronically anticoagulated patient,” Journal of Thrombosis and Thrombolysis, vol. 12, no. 1, pp. 81–87, 2001. View at Publisher · View at Google Scholar · View at Scopus
  42. “Fresh frozen plasma: indications and risks,” NIH Consensus Statement, vol. 5, no. 5, pp. 1–12, September 1984.
  43. K. Fredriksson, B. Norrving, and L. G. Stromblad, “Emergency reversal of anticoagulation after intracerebral hemorrhage,” Stroke, vol. 23, no. 7, pp. 972–977, 1992. View at Google Scholar · View at Scopus
  44. J. Bux, “Transfusion-related acute lung injury (TRALI): a serious adverse event of blood transfusion,” Vox Sanguinis, vol. 89, no. 1, pp. 1–10, 2005. View at Publisher · View at Google Scholar · View at Scopus
  45. M. Köhler, P. Hellstern, E. Lechler, P. Überfuhr, and G. Müller-Berghaus, “Thromboembolic complications associated with the use of prothrombin complex and factor IX concentrates,” Thrombosis and Haemostasis, vol. 80, no. 3, pp. 399–402, 1998. View at Google Scholar · View at Scopus
  46. S. M. Jafri, “Periprocedural thromboprophylaxis in patients receiving chronic anticoagulation therapy,” American Heart Journal, vol. 147, no. 1, pp. 3–15, 2004. View at Publisher · View at Google Scholar · View at Scopus