Novel Vitamin D Analogs for Prostate Cancer Therapy

Figure 3

Comparison of the effect of 1α,25(OH)₂D₃ and 19-nor-1α,25(OH)₂D₃ on the ³H-thymidine incorporation in (a) LNCaP cells and (b) the primary cultures of prostate cancer cells. Results are presented as the means ± SD of 5–8 determinations. There is no difference between 1α,25(OH)₂D₃ and 19-nor-1α,25(OH)₂D₃ at any dose levels examined. ^∗𝑃<0.05,^∗∗𝑃<0.001 versus controls.

(a)

(b)