Helicobacter pylori Induces Disturbances in Gastric Mucosal Akt Activation through Inducible Nitric Oxide Synthase-Dependent S-Nitrosylation: Effect of Ghrelin

Figure 4

Effect of ghrelin on H. pylori LPS-induced changes in gastric mucosal cell Akt kinase threonine (Thr³⁰⁸) and serine (Ser⁴⁷³) phosphorylation. The cells, preincubated with the indicated concentrations of ghrelin, were treated with the LPS at 100 ng/ml and incubated for 16 h. Values represent the means $\pm$ SD of five experiments. ${}^{*}P<.05$ compared with that of control. ${}^{**}P<.05$ compared with that of LPS alone.