Table of Contents
ISRN Obstetrics and Gynecology
Volume 2011 (2011), Article ID 313206, 3 pages
Clinical Study

Second Trimester Amniocentesis Is Not a Risk Factor for Very Low Birth Weight and Extremely Low Birth Weight

1Prenatal Medicine Unit, Department of Obstetrics and Gynecology, University of Modena and Reggio Emilia, 41121 Modena, Italy
2Department of Neonatal Intensive, University of Modena and Reggio Emilia, 41121 Modena, Italy
3Medical Genetics, University of Modena and Reggio Emilia, 41121 Modena, Italy

Received 19 April 2011; Accepted 31 May 2011

Academic Editors: K. Chan, N. A. Ginsberg, and M. Kühnert

Copyright © 2011 Vincenzo Mazza et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objectives. To assess the risk of very low birth weight (VLBW) and extremely low birth weight (ELBW) attributable to second trimester amniocentesis. Methods. Records of 4,877 consecutive amniocentesis, performed between 1997 and 2003, were analyzed. Only VLBW and ELBW in the study population (exposed) and in the control group (unexposed) were evaluated. Comparisons were made between the amniocentesis group versus nonexposed. Odds ratios (OR) and 95% confidence intervals (95% CI) were calculated for VLBW and ELBW classes. Results. In the study population, the VLBW were 35 (0.71%) and the ELBW were 20 (0.41%). In the control group, the VLBW were 220 (0.67%) and the ELBW were 112 (0.34%). The Odds ratios of the VLBW between the study and the control group did not show any statistical significant risk (OR = 1.07, 95% CI = 0.72–1.54). Also in ELBW odds ratios between study and control group were not statistically significant (OR = 1.20, 95% CI = 0.7–1.95). Conclusions. No effect of the second trimester amniocentesis was noted on VLBW and ELBW.