Table of Contents
ISRN Pediatrics
Volume 2011 (2011), Article ID 380283, 7 pages
http://dx.doi.org/10.5402/2011/380283
Clinical Study

The Use of Dexamethasone in Bacterial Meningitis in Children and Adults: A Retrospective Analysis

Pediatric Critical Care Medicine Department, Universitair Ziekenhuis Brussel, 1090 Brussels, Belgium

Received 29 September 2011; Accepted 4 November 2011

Academic Editors: M. Adhikari and S. A. Sarker

Copyright © 2011 An-Sophie Cornelis and Said Hachimi-Idrissi. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Bacterial meningitis is a life-threatening illness that results from bacterial infection of the meninges and is associated with high mortality and morbidity rate, especially when the Streptococcus pneumoniae is the causative agent. Dexamethasone as adjunctive therapy to antibiotics does not influence the outcome or the complications in children as well as in adults suffering bacterial meningitis. However, we identified some prognostic parameters in the outcome of bacterial meningitis, and when dexamethasone was given in presence of at least one of 3 poor prognostic CSF parameters (WBC < 1000/mm3, glucose < 20 mg/dl, lactate > 10 mg/dl) it substantially improved the outcome.