Table of Contents
ISRN Materials Science
Volume 2011 (2011), Article ID 392763, 6 pages
Research Article

Genetic Effects of Trabecular Titanium on MG-63 Cell Line: A Genetic Profiling Evaluation

1Orthopaedic Institute, University of Ferrara, Corso Giovecca 203, 44100 Ferrara, Italy
2Department of Histology, Embryology and Applied Biology, University of Bologna, 40126 Bologna, Italy
3Department of Maxillofacial Surgery, University of Ferrara, 44121 Ferrara, Italy
4Lima Corporate, 30030 S. Daniele del Friuli , Italy

Received 13 April 2011; Accepted 9 May 2011

Academic Editors: E. Burkel and K. Kusabiraki

Copyright © 2011 Sollazzo Vincenzo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Pure titanium and titanium alloys are materials widely used in orthopaedics because of their mechanical properties, chemical stability, and biocompatibility. Recently, a new highly porous titanium biomaterial named Trabecular Titanium (TT) has been developed. In this in vitro study, we tested the genetic effects of TT on osteoblast-like cells (MG63) using DNA microarrays technology: cDNA microarrays provides the ability to comparatively analyze mRNA expression of thousands of genes in parallel thus showing activated and repressed genes by the presence of the TT. Several genes that were significantly up- or downregulated have been identified. Globally, it was demonstrated that TT stimulates osteoblasts proliferation and differentiation, and reduces apoptosis. Therefore, all these effects can contribute to improve the osseointegration of this material. These results encourage the clinical application of Trabecular Titanium to prosthetic devices.