c-kit and bcl-2 Are Not Useful Markers in Differentiating Adenoid Cystic Carcinoma from Polymorphous Low-Grade Adenocarcinoma
Staining patterns in ACC and PLGA. ACC showing a focal cribriform growth pattern as well as areas of streaming mimicking a PLGA (a) (H&E, ×20) and a PLGA with biphasic structures resembling ACC (b) (H&E, ×40). Marked (>60%) granular cytoplasmic bcl-2 protein expression in the cribriform variant of ACC (c) and the tubular type of PLGA (d) (bcl-2, ×40). Intense c-kit membranous and cytoplasmic immunopositivity (>60%) of the luminal cells in ACC (e); weak (<30%) cytoplasmic and membranous staining in PLGA (f) (c-kit, ×40).
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