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ISRN Immunology
Volume 2011 (2011), Article ID 426095, 7 pages
Review Article

PICOT: A Multidomain Protein with Multiple Functions

The Shraga Segal Department of Microbiology and Immunology, Faculty of Health Sciences and the Cancer Research Center, Ben-Gurion University of the Negev, P.O. Box 653, Beer-Sheva 84105, Israel

Received 3 August 2011; Accepted 18 August 2011

Academic Editors: S.-I. Fujii, D. L. Jankovic, and P. Kisielow

Copyright © 2011 Anna Keselman et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The PICOT protein possesses three highly conserved regions that include an aminoterminal thioredoxin-like homology domain and a tandem repeat of a carboxyterminal PICOT homology domain with an overall conformation that resembles a glutaredoxin homology domain. In contrast to the classical dithiol thioredoxins and glutaredoxins, PICOT possesses a single cysteine residue in each of its three domains and is therefore distinct from the classical thioredoxin and glutaredoxin redox enzymes. Recent studies demonstrated that PICOT is a prerequisite for mouse embryogenesis and participates in several independent biological systems in the adult. This paper examines advances made over the past few years in understanding the role of PICOT in various biological systems.