Carvedilol-Afforded Protection against Daunorubicin-Induced Cardiomyopathic Rats <i>In Vivo</i>: Effects on Cardiac Fibrosis and Hypertrophy

<table>(a) Hematoxylin and eosin staining of the cross-sectional tissue slices of hearts depicting interstitial edema, vacuolization, and degeneration of cardiac fibers (X200). (b) Hematoxylin and eosin staining of the cross-sectional tissue slices of hearts depicting cardiac hypertrophy (X400), (c) Azan-Mallory staining for fibrosis of the cross-sectional tissue slices of hearts. Fibrosis is indicated by the blue area as opposed to the red myocardium (X200). (d) Bar graph showing % fibrosis in each experimental group. Each bar represents mean ± S.E.M. Group control (C) age-matched normal rats; group DNR, DNR-treated rats administered with vehicle; group Carv, DNR-treated rats administered with carvedilol (30 mg/kg/day). <svg height="15.4375" id="M74" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 57.287498 15.4375" width="57.287498" xmlns="http://www.w3.org/2000/svg">
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<tspan style="font-size: 8.75px; " x="0" y="0">∗</tspan>
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<tspan style="font-size: 12.50px; " x="0" y="0">𝑃</tspan>
<tspan style="font-size: 12.50px; " x="10.9" y="-0.95999998">&lt;</tspan>
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<tspan style="font-size: 12.50px; " x="26.053637" y="-0.95999998">0</tspan>
<tspan style="font-size: 12.50px; " x="32.305138" y="-0.95999998">5</tspan>
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</svg> versus group Control; <svg height="17.525" id="M75" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 57.025002 17.525" width="57.025002" xmlns="http://www.w3.org/2000/svg">
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<tspan style="font-size: 12.50px; " x="0" y="0">𝑃</tspan>
<tspan style="font-size: 12.50px; " x="10.9" y="-0.94999999">&lt;</tspan>
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<tspan style="font-size: 12.50px; " x="32.305138" y="-0.94999999">5</tspan>
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</svg> versus group DNR.</table>

International Scholarly Research Notices

fig1

Figure 1

Figure 1: Carvedilol-Afforded Protection against Daunorubicin-Induced Cardiomyopathic Rats <i>In Vivo</i>: Effects on Cardiac Fibrosis and Hypertrophy 

International Scholarly Research Notices

Carvedilol-Afforded Protection against Daunorubicin-Induced Cardiomyopathic Rats In Vivo: Effects on Cardiac Fibrosis and Hypertrophy

Figure 1