Table of Contents
ISRN Oncology
Volume 2011, Article ID 451086, 7 pages
http://dx.doi.org/10.5402/2011/451086
Research Article

Olfactory Neuroblastomas: An Experience of 24 Years

1Division of Medical Oncology, Department of Internal Medicine, Cerrahpasa Medical Faculty, Istanbul University, 34098 Istanbul, Turkey
2Deparment of Radiation Oncology, Medical Park Hospital, Antalya, Turkey
3Department of Pathology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey
4Department of Radiation Oncology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey
5Division of Medical Oncology, Department of Internal Medicine, Istanbul Bilim University, Istanbul, Turkey

Received 16 March 2011; Accepted 17 April 2011

Academic Editor: M. Amichetti

Copyright © 2011 Deniz Tural et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. The aim of this study was to evaluate clinicopathological findings and the efficacy of the treatment modalities used in patients with olfactory neuroblastomas. Study Design. Retrospective record review. Setting. Istanbul University, Cerrahpasa Medical Faculty, medical oncology outpatient clinic. Subjects and Methods. There were 3 stage A tumors, 5 stage B and 11 stage C according to the Kadish staging system. There were 5 grade I/II and 12 grade III/IV according to the Hyams' histopathologic system. Involvement to orbita was detected in eight patients at the time of diagnosis. Results. The median follow-up period was 23.7 months. The 5-year survival rate for the whole group was 26%. The stage A/B groups exhibited a better survival rate than the C group with 2-year survival rates being 25 versus 71% respectively ( 𝑃 = . 0 0 8 ). The grade I/II groups exhibited a better survival rate than the grade III/IV groups with 2-year survival rates being 50 versus 16% respectively ( 𝑃 = . 0 0 1 ). The group who had orbital involvement exhibited a poor survival rate than the group of patients who had no involvement of the orbital. Conclusion. In our study, tumor stage, histopathologic grading, involvement of the orbita, brain and bone marow metastases were the statistically significant prognostic factors.