Table of Contents
ISRN Cardiology
Volume 2011, Article ID 457247, 5 pages
http://dx.doi.org/10.5402/2011/457247
Review Article

Genetic Polymorphisms as Risk Stratification Tool in Primary Preventive ICD Therapy

1Abteilung für Kardiologie und Kreislauferkrankungen, Klinikum der Eberhard-Karls-Universität Tübingen, 72076 Tübingen, Germany
2Klinik und Poliklinik für Innere Medizin B, Klinikum der Ernst-Moritz-Arndt-Universität Greifswald 17475 Greifswald, Germany

Received 20 February 2011; Accepted 8 April 2011

Academic Editors: M. Fito Colomer, L. Liaudet, and P. Meier

Copyright © 2011 Roman Laszlo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

More and more implantable cardioverter-defibrillators (ICDs) are implanted as primary prevention of sudden cardiac death (SCD). However, major problem in practice is to identify high-risk patients for SCD. Different methods for noninvasive risk stratification do not have a sufficient positive or negative predictive value. Since current approaches lead to implantation of ICDs in a large number of patients who will never suffer an arrhythmic event and simultaneously patients still die of SCD who currently did not seem eligible for primary preventive ICD implantation, there is a need for additional tools for risk stratification. Epidemiological studies point to a hereditary risk of SCD. Different susceptibility of each person concerning arrhythmogenic events might be explained by genetic polymorphisms. By obtaining an individual “pattern” of polymorphisms of genes encoding for proteins which are important in arrhythmogenesis in one patient, risk stratification in primary prevention of SCD might by improved.