TY - JOUR A2 - Martinez, C. A2 - Knecht, H. A2 - Oberg, F. AU - Giordano, P. C. AU - Huisman, W. AU - Harteveld, C. L. PY - 2011 DA - 2011/07/05 TI - Iron Depletion: An Ameliorating Factor for Sickle Cell Disease? SP - 473152 VL - 2011 AB - We report some observations from our laboratory practice that might be important for the treatment of sickle cell disease (SCD). We describe data from two cases indicating that iron depletion might have a beneficial effect diminishing the formation of HbS infavor of HbF, possibly reducing the severity of the disease. We believe that it would be worthwhile to monitor the course of the disease comparing cases with identical genotypes with and without iron depletion, and we advise to consider chelation therapy to reduce iron overload in patients with SCD. SN - null UR - https://doi.org/10.5402/2011/473152 DO - 10.5402/2011/473152 JF - ISRN Hematology PB - International Scholarly Research Network KW - ER -