Table of Contents
ISRN Nanotechnology
Volume 2011, Article ID 503158, 6 pages
http://dx.doi.org/10.5402/2011/503158
Research Article

Development of Topical Niosomal Gel of Benzoyl Peroxide

1Pharmacy Department, The M. S. University of Baroda, G. H. Patel Building, Baroda, Gujarat 390002, India
2Pharmaceutics Department, Sigma Institute of Pharmacy, Baroda, Gujarat 390022, India
3Pharmaceutical Chemistry Department, Sigma Institute of Pharmacy, Baroda, Gujarat 390022, India

Received 5 April 2011; Accepted 30 April 2011

Academic Editors: N. Shukla and H. Tang

Copyright © 2011 Jigar Vyas et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Benzoyl peroxide is macrolide antibiotic used commonly for the treatment of acne either alone or in combination. But it suffers from side effects like skin redness, irritation, itching, and edema. Niosomes, a nonionic surfactant vesicular formulation, have been explored extensively for topical application to enhance skin penetration as well as to improve skin retention of drugs. In the present study, Benzoyl peroxide was entrapped into niosomes by thin film hydration technique, and various process parameters were optimized by partial factorial design. The optimized niosomal formulation was incorporated into HPMC K15 gel and extensively characterized for percentage drug entrapment (PDE) and in vitro release performance. The stability of above formulation was studied at different temperatures. The present study demonstrated prolongation of drug release, increased drug retention into skin, and improved permeation across the skin after encapsulation of benzoyl peroxide into niosomal topical gel.