Research Article

Development of Topical Niosomal Gel of Benzoyl Peroxide

Table 1

Table shows optimization experiments for selection of surfactant.

Formulation
Code
Span 20Span 60Span 80Percentage drug entrapments ± %SDAverage particle size ± %SD

NF11 : 0 (−1)1 : 0 (−1)1 : 0 (−1)No niosomes without surfactant
NF21 : 0 (−1)1 : 0 (−1)1 : 1 (+1)82.26% (±1.89)4.67 (±0.088)
NF31 : 0 (−1)1 : 1 (+1)1 : 0 (−1)52.55% (±1.65)6.87 (±0.317)
NF41 : 0 (−1)1 : 1 (+1)1 : 1 (+1)70.62% (±2.25)3.39 (±0.078)
NF51 : 1 (+1)1 : 0 (−1)1 : 0 (−1)29.23% (±0.96)6.87 (±0.317)
NF61 : 1 (+1)1 : 0 (−1)1 : 1 (+1)49.51% (±1.35)6.13 (±0.199)
NF71 : 1 (+1)1 : 1 (+1)1:0 (−1)39.19% (±1.28)4.13 (±0.170)
NF81 :  1 (+1)1 :  1 (+1)1 : 1 (+1)47.95% (±1.96)6.87 (±0.317)

𝑛 = 3 ; the two levels of study −1 = 1 : 0 and +1 = 1 : 1 are in the form of drug  :  surfactant molar ratio.