Research Article
Development of Topical Niosomal Gel of Benzoyl Peroxide
Table 1
Table shows optimization experiments for selection of surfactant.
| Formulation Code | Span 20 | Span 60 | Span 80 | Percentage drug entrapments ± %SD | Average particle size ± %SD |
| NF1 | 1 : 0 (−1) | 1 : 0 (−1) | 1 : 0 (−1) | No niosomes without surfactant | NF2 | 1 : 0 (−1) | 1 : 0 (−1) | 1 : 1 (+1) | 82.26% (±1.89) | 4.67 (±0.088) | NF3 | 1 : 0 (−1) | 1 : 1 (+1) | 1 : 0 (−1) | 52.55% (±1.65) | 6.87 (±0.317) | NF4 | 1 : 0 (−1) | 1 : 1 (+1) | 1 : 1 (+1) | 70.62% (±2.25) | 3.39 (±0.078) | NF5 | 1 : 1 (+1) | 1 : 0 (−1) | 1 : 0 (−1) | 29.23% (±0.96) | 6.87 (±0.317) | NF6 | 1 : 1 (+1) | 1 : 0 (−1) | 1 : 1 (+1) | 49.51% (±1.35) | 6.13 (±0.199) | NF7 | 1 : 1 (+1) | 1 : 1 (+1) | 1:0 (−1) | 39.19% (±1.28) | 4.13 (±0.170) | NF8 | 1 : 1 (+1) | 1 : 1 (+1) | 1 : 1 (+1) | 47.95% (±1.96) | 6.87 (±0.317) |
|
|
; the two levels of study −1 = 1 : 0 and +1 = 1 : 1 are in the form of drug : surfactant molar ratio.
|