Research Article
Development of Topical Niosomal Gel of Benzoyl Peroxide
Table 3
Table explains optimization of volume of hydration and time of hydration.
| Formulation
code | Volume of
hydration | Time of
hydration | Percentage drug entrapments ± %SD | Average particle size ± %SD |
| | NF13 | 3 (−1) | 0.5 (−1) | 70.05% (±0.80) | 7.77 (±0.31) | | NF14 | 3 (−1) | 1.0 (0) | 75.26% (±2.39) | 4.67 (±0.09) | | NF15 | 3 (−1) | 2.0 (+1) | 79.55% (±2.10) | 6.87 (±0.32) | | NF16 | 5 (0) | 0.5 (−1) | 70.62% (± 2.25) | 3.39 (±0.08) | | NF17 | 5 (0) | 1.0 (0) | 82.26% (±1.89) | 4.67 (±0.08) | | NF18 | 5 (0) | 2.0 (+1) | 88.51% (±1.30) | 4.11 (±0.19) | | NF19 | 7 (+1) | 0.5 (−1) | 69.19% (±1.88) | 4.13 (±0.17) | | NF20 | 7 (+1) | 1.0 (0) | 77.95% (±1.96) | 6.87 (±0.30) | | NF21 | 7 (+1) | 2.0 (+1) | 92.12% (±2.43) | 4.78 (±0.09) |
|
|
; batch NF13 was taken with all other parameter constant except parameters shown above.
|
