Research Article
Development of Topical Niosomal Gel of Benzoyl Peroxide
Table 7
Table shows data of diffusion study of drug across human cadaver skin (HCS).
| | Time in hours | | Percentage drug release (±SD) | | | Batch C1 | Batch C2 | Market Prep. |
| | 0.5 | — | — | — | | 1 | 07.97 (±0.54) | — | 9.98 (±0.27) | | 2 | 17.34 (±0.89) | 09.24 (±1.20) | 18.84 (±0.67) | | 3 | 24.45 (±0.76) | 15.11 (±1.86) | 26.33 (±0.91) | | 5 | 36.63 (±1.94) | 21.76 (±1.13) | 39.08 (±1.40) | | 8 | 48.43 (±2.35) | 28.83 (±2.09) | 51.23 (±1.34) | | 12 | 59.42 (±3.01) | 32.31 (±2.34) | 63.67 (±2.89) |
| | | Percentage drug retained into human cadaver skin (HCS) after 12 hours | | | 24 | 21.45 (±0.36) | 41.53 (±1.75) | 24.88 (±0.49) |
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; little or no release was observed in first hour which landed difficulties in the quantification.
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