Brain Metastases from Ovarian Carcinoma

Table 2

Type, amount and site of CNS metastases from ovarian carcinoma.

		Type and amount of CNS metastases				Site of metastases in the brain parenchyma
		Number of patients (%)				Number of patients
Author (year) [ref.]	Number of patients with CNS metastases	Isolated	Brain parenchyma single (solitary)	Brain parenchyma Multiple	LM disease	NS	Cerebrum	Cerebellum	Cerebrum and cerebellum
Mayer et al. (1978) [13]	6	1 (17)	3 (50)	1 (17)	2 (33)	0	3	1	0
Barker et al. (1981) [24]	4	1 (25)	3 (75)	1 (25)	0 (0)	0	2	2	0
Larson et al. (1986) [20]	13	5 (38)	5 (38)	7 (54)	1 (8)	12	0	0	0
Stein et al. (1986) [26]	5	4 (80)	2 (40)	2 (40)	1 (20)	4	0	0	0
Dauplat et al. (1987) [27]	5	1 (20)	3 (60)	2 (40)	0 (0)	0	4	1	0
Ziegler et al. (1987) [28]	5	2 (40)	3 (60)	2 (40)	0 (0)	1	1	3	0
Ross et al. (1988) [29]	7	3 (43)	4 (57)	2 (29)	1 (14)	0	5	1	0
Hardy and Harvey (1989) [30]	6	4 (67)	NA	NA	NA	6	0	0	0
Piura et al. (1990) [31]	2	1 (50)	2 (100)	0 (0)	0 (0)	0	2	0	0
Plaxe et al. (1990) [32]	6	5 (83)	0 (0)	5 (83)	1 (17)	0	0	4	1
LeRoux et al. (1991) [33]	14	6 (43)	9 (64)	5 (36)	0 (0)	0	14	0	0
Rodriguez et al. (1992) [34]	16	11 (69)	5 (31)	10 (63)	1 (6)	15	0	0	0
Bruzzone et al. (1993) [35]	9	2 (22)	NA	NA	NA	9	0	0	0
Salvati and Cervoni (1994) [36]	4	4 (100)	4 (100)	0 (0)	(0)	0	4	0	0
Geisler and Geisler (1995) [37]	16	8 (50)	8 (50)	8 (50)	0 (0)	0	14	2	0
Cormio et al. (1995) [38]	23	9 (39)	9 (39)	13 (56)	1 (4)	0	18	4	0
Zhao et al. (1999) [40]	4	2 (50)	3 (75)	1 (25)	0 (0)	4	0	0	0
Kaminsky-Forrett et al. (2000) [41]	8	1 (13)	6 (75)	2 (25)	0 (0)	0	3	3	2
Sanderson et al. (2002) [42]	13	5 (38)	4 (31)	8 (62)	1 (8)	0	10	2	0
Anupol et al. (2002) [43]	15	8 (57)	7 (47)	7 (47)	1 (7)	14	0	0	0
Kolomainen et al. (2002) [21]	18	8 (44)	9 (50)	9 (50)	0 (0)	18	0	0	0
Pothuri et al. (2002) [44]	14	7 (50)	12 (86)	2 (14)	0 (0)	0	11	3	0
Kumar et al. (2003) [45]	18	5 (28)	5 (28)	12 (67)	1 (5)	0	13	2	2
Li and Fu (2003) [46]	10	0 (0)	2 (20)	8 (80)	0 (0)	0	10	0	0
Cohen et al. (2004) [47]	72	31 (43)	25 (35)	44 (61)	3 (4)	0	63	6	0
Tay and Rajesh (2005) [48]	4	0 (0)	0 (0)	3 (75)	1 (25)	0	3	0	0
Pectasides et al. (2005) [49]	17	13 (76)	5 (29)	12 (71)	0 (0)	17	0	0	0
D’Andrea et al. (2005) [50]	11	11 (100)	11 (100)	0 (0)	0 (0)	0	9	2	0
Chen et al. (2005) [51]	19	9 (47)	7 (37)	12 (63)	0 (0)	19	0	0	0
Kastritis et al. (2006) [52]	8	2 (25)	4 (50)	4 (50)	0 (0)	0	6	2	0
Kim et al. (2007) [53]	13	6 (46)	2 (15)	11 (85)	0 (0)	0	6	1	6
Lee et al. (2008) [54]	15^a	10 (67)	5 (33)	10 (67)	0 (0)	15	0	0	0
Sehouli et al. (2010) [55]	74	39 (52.7)	26 (35)	48 (65)	0 (0)	74	0	0	0
Chen et al. (2011) [22]	10	3 (30)	1 (10)	9 (90)	0 (0)	10	0	0	0
Cormio et al. (2011) [56]	20	9 (45)	11 (55)	9 (45)	0 (0)	6	9	5	0
Total	504	236 (46.8)	205 (41.9)^b	269 (55)^b	15 (3.1)^b	224 (45.8)^c	210 (42.9)^c	44 (9)^c	11 (2.3)^c

CNS: central nervous system; LM: leptomeningeal; NS: not specified; NA: not available.
^aThere were 18 patients with BM; however, data were analyzed for 15 patients treated with gamma-knife surgery (GKS) or whole brain radiotherapy (WBRT).
^bPercentage is calculated for 489 patients in whom amount and distribution of CNS metastases is available.
^cPercentage is calculated for 489 patients with parenchymal brain metastases.