Table of Contents
ISRN Obstetrics and Gynecology
Volume 2011 (2011), Article ID 575327, 8 pages
http://dx.doi.org/10.5402/2011/575327
Clinical Study

Clinicopathological Characteristics and Her-2/neu Status in Chinese Patients with Uterine Papillary Serous Carcinoma

1Department of Gynecologic Oncology, Fudan University Shanghai Cancer Center, China
2Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China
3Department of Pathology, Fudan University Shanghai Cancer Center, China

Received 14 September 2010; Accepted 13 October 2010

Academic Editors: L. Gebrim and L. B. Twiggs

Copyright © 2011 Yulan Ren et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. To analyze clinico-pathological features of Chinese patients with UPSC, and investigate roles of Her-2/neu protein expression and gene amplification in UPSC prognosis. Methods. Thirty-six patients with UPSC treated in Cancer Hospital of Fudan University from 1996 to 2006 were analysed retrospectively. Chromogenic in situ hybridization (CISH) and immunohistochemistry (IHC) were performed to evaluate Her-2/neu gene amplification and protein expression respectively. Results. The median age was 63 years, and 61% (22/36) were late stages (stage III/IV). The 1-year, 3-year, and 5-year overall survival (OS) was 73.1%, 51.9% and 43.9%, respectively. Advanced stages ( 𝑃 = . 0 0 0 6 ) and deep myometrial invasion ( 𝑃 = . 0 1 3 8 ) were significantly associtated with a shorter OS. In 36 cases, 27.8% (10/36) showed 2 + staining and 8.3% (3/36) showed 3 + by IHC. Amplification of the Her-2/neu gene was observed in 11.1% (4/36) cases. The 5-year overall survival rate in Her-2/neu IHC 2 + ∼ 3 + and 0 ∼ 1 + cases was 12.9% and 68.6% respectively. Her-2/neu protein expression 2 + ∼ 3 + was significantly associated with advanced surgical stage and worse overall survival ( 𝑃 = . 0 3 and 𝑃 = . 0 0 2 3 , resp.). Conclusion. Chinese patients with UPSC showed characteristics of deep myometrial invasion, advanced stages and poor overall survival. Her-2/neu protein overexpression is associated with advanced stage and poor survival outcome.