Use of Pattern Recognition Analysis to Identify Underlying Relationships of Doxorubicin Derivatives Optimized for Breast Cancer Treatment
Figure 1
Comparative structures of doxorubicin and eight analogs. Note that doxorubicin (drug A) possesses a hydroxyl ketone group (see insert circle) that can be varied widely to form other compounds with variation in and aqueous solubility. Drug B retains this hydroxy ketone group; however, an imine group replaces the original primary amine group on the daunosamine sugar substituent (see insert arrow). All other compounds form an alkoxy (βOR) homologous series of doxorubicin at the former hydroxy ketone group.
