Table of Contents
ISRN Pediatrics
Volume 2011, Article ID 712560, 4 pages
http://dx.doi.org/10.5402/2011/712560
Case Report

A Case of Pemphigus Herpetiformis in a 12-Year-Old Male

1Dermatology Department, School of Medicine, Cadi Ayyad University, Mohammed the VIth University Hospital Marrakesh, Morocco
2Paediatrics Department, School of Medicine, Cadi Ayyad University, Mohammed the VIth University Hospital Marrakesh, Morocco
3Pathology Group laboratory of Marrakesh, Morocco

Received 27 January 2011; Accepted 16 March 2011

Academic Editors: M. Adhikari and R. Bhimma

Copyright © 2011 O. Hocar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Pemphigus herpetiformis (PH) is one of the less common forms of pemphigus. PH in children is unreported. We describe a case of a child who developed PH. Observation. A 12-year-old boy was seen at our department with erosive plaques, vesicles, and crusted cutaneous lesions associated with severe itching persisting for six months. Histologic examination showed an intraepidermal bulla containing rare acantholytic epidermal cells with eosinophilic spongiosis. Direct immunofluorescence demonstrated intercellular Ig G and C3 deposit. The serum titer of antibodies against intercellular epidermal was 1/200 UI/l. Diagnosis of PH was made, and treatment with Dapsone 2 mg/kg per day resulted in total clinical remission. However, two months later, new vesicles reappeared and treatment was begun with prednisone at a dose of 2 mg/kg daily. There was a very good response. Discussion. Childhood pemphigus herpetiformis is a rare disease, often initially misdiagnosed. It must not be forgotten that the disease is a possible cause of erosive mucocutaneous disease in children.