Table of Contents
ISRN Endocrinology
Volume 2011, Article ID 732623, 4 pages
Case Report

Successful Treatment of Methimazole-Induced Severe Aplastic Anemia by Granulocyte Colony-Stimulating Factor, Methylprednisolone, and Cyclosporin

1Fourth Department of Medicine, Teikyo University School of Medicine, Kawasaki, Japan
2Department of Endocrinology and Metabolism, Mishuku Hospital, 5-33-12 Kamimeguro, Meguro-ku, Tokyo 153-0051, Japan

Received 17 January 2011; Accepted 24 February 2011

Academic Editors: A. De Bellis and O. Nilsson

Copyright © 2011 Munehiro Honda. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A 52-year-old Japanese woman was examined because of general malaise, weight loss and a lump in her left breast. She was diagnosed with cancer of the left breast and Graves' disease, and was administered methimazole (MMI). A left mastectomy was performed for the breast cancer. She presented with a high fever and peripheral blood examination revealed a severe pancytopenia. She was diagnosed with severe aplastic anemia, and administered G-CSF, however, the treatment was unsuccessful. Thus, oral methyprednisolone and cyclosporin were added. There was a remarkable improvement in the peripheral blood count.