Structural and Functional Characterization of a New Double Variant Haemoglobin (HbG-Philadelphia/Duarte <svg style="vertical-align:-6.94061pt;width:189.825px;" id="M1" height="31.049999" version="1.1" viewBox="0 0 189.825 31.049999" width="189.825"  xmlns="http://www.w3.org/2000/svg">
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			<text transform="matrix(1,0,0,-1,-71.95,54.12)">
				<tspan style="font-size: 17.93px; " x="0" y="0">𝛼</tspan>
			</text>

			<text transform="matrix(1,0,0,-1,-61.84,63.31)">
				<tspan style="font-size: 12.55px; " x="0" y="0">𝟔</tspan>
				<tspan style="font-size: 12.55px; " x="6.2765002" y="0">𝟖</tspan>
			</text>

			<text transform="matrix(1,0,0,-1,-49.28,63.31)">
				<tspan style="font-size: 12.55px; " x="0" y="0">A</tspan>
				<tspan style="font-size: 12.55px; " x="9.0632658" y="0">s</tspan>
				<tspan style="font-size: 12.55px; " x="13.946383" y="0">n</tspan>
			</text>

			<text transform="matrix(1,0,0,-1,-26.97,63.31)">
				<tspan style="font-size: 12.55px; " x="0" y="0">→</tspan>
			</text>

			<text transform="matrix(1,0,0,-1,-13.25,63.31)">
				<tspan style="font-size: 12.55px; " x="0" y="0">L</tspan>
				<tspan style="font-size: 12.55px; " x="7.2054219" y="0">y</tspan>
				<tspan style="font-size: 12.55px; " x="13.318733" y="0">s</tspan>
			</text>

			<text transform="matrix(1,0,0,-1,-61.84,47.21)">
				<tspan style="font-size: 12.55px; " x="0" y="0">𝟐</tspan>
			</text>

			<text transform="matrix(1,0,0,-1,5.45,54.12)">
				<tspan style="font-size: 17.93px; " x="0" y="0">𝛽</tspan>
			</text>

			<text transform="matrix(1,0,0,-1,15.45,61.39)">
				<tspan style="font-size: 12.55px; " x="0" y="0">𝟔</tspan>
				<tspan style="font-size: 12.55px; " x="6.2765002" y="0">𝟐</tspan>
			</text>

			<text transform="matrix(1,0,0,-1,28.01,61.39)">
				<tspan style="font-size: 12.55px; " x="0" y="0">A</tspan>
				<tspan style="font-size: 12.55px; " x="9.0632658" y="0">l</tspan>
				<tspan style="font-size: 12.55px; " x="12.553" y="0">a</tspan>
			</text>

			<text transform="matrix(1,0,0,-1,48.23,61.39)">
				<tspan style="font-size: 12.55px; " x="0" y="0">→</tspan>
			</text>

			<text transform="matrix(1,0,0,-1,61.94,61.39)">
				<tspan style="font-size: 12.55px; " x="0" y="0">P</tspan>
				<tspan style="font-size: 12.55px; " x="6.9920211" y="0">r</tspan>
				<tspan style="font-size: 12.55px; " x="11.109405" y="0">o</tspan>
			</text>

			<text transform="matrix(1,0,0,-1,15.45,47.86)">
				<tspan style="font-size: 12.55px; " x="0" y="0">𝟐</tspan>
			</text>

		</g>
	</g>
</svg>)

<table>Xrms of (black curves) Deoxy HbA  and  (red curves) HbG-Philadelphia/Duarte. (a) Tetramer, (b)–(e) <svg height="13.55" id="M82" style="vertical-align:-2.29482pt" version="1.1" viewbox="0 0 16.6625 13.55" width="16.6625" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,13.55)">
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<text transform="matrix(1,0,0,-1,-71.95,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝛽</tspan>
<tspan style="font-size: 12.50px; " x="6.9641709" y="0">2</tspan>
</text>
</g>
</g>
</svg>, <svg height="10.85" id="M83" style="vertical-align:-0.1254pt" version="1.1" viewbox="0 0 16.75 10.85" width="16.75" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,10.85)">
<g transform="translate(72,-63.32)">
<text transform="matrix(1,0,0,-1,-71.95,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝛼</tspan>
<tspan style="font-size: 12.50px; " x="7.0391889" y="0">2</tspan>
</text>
</g>
</g>
</svg>, <svg height="13.55" id="M84" style="vertical-align:-2.29482pt" version="1.1" viewbox="0 0 16.6625 13.55" width="16.6625" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,13.55)">
<g transform="translate(72,-61.16)">
<text transform="matrix(1,0,0,-1,-71.95,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝛽</tspan>
<tspan style="font-size: 12.50px; " x="6.9641709" y="0">1</tspan>
</text>
</g>
</g>
</svg>, and <svg height="10.85" id="M85" style="vertical-align:-0.1254pt" version="1.1" viewbox="0 0 16.75 10.85" width="16.75" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,10.85)">
<g transform="translate(72,-63.32)">
<text transform="matrix(1,0,0,-1,-71.95,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝛼</tspan>
<tspan style="font-size: 12.50px; " x="7.0391889" y="0">1</tspan>
</text>
</g>
</g>
</svg> chains, respectively.</table>

International Scholarly Research Notices

fig8

Figure 8

Figure 8: Structural and Functional Characterization of a New Double Variant Haemoglobin (HbG-Philadelphia/Duarte <svg style="vertical-align:-6.94061pt;width:189.825px;" id="M1" height="31.049999" version="1.1" viewBox="0 0 189.825 31.049999" width="189.825"  xmlns="http://www.w3.org/2000/svg">
	<g transform="matrix(1.25,0,0,-1.25,0,31.05)">
		<g transform="translate(72,-47.16)">
			<text transform="matrix(1,0,0,-1,-71.95,54.12)">
				<tspan style="font-size: 17.93px; " x="0" y="0">𝛼</tspan>
			</text>

			<text transform="matrix(1,0,0,-1,-61.84,63.31)">
				<tspan style="font-size: 12.55px; " x="0" y="0">𝟔</tspan>
				<tspan style="font-size: 12.55px; " x="6.2765002" y="0">𝟖</tspan>
			</text>

			<text transform="matrix(1,0,0,-1,-49.28,63.31)">
				<tspan style="font-size: 12.55px; " x="0" y="0">A</tspan>
				<tspan style="font-size: 12.55px; " x="9.0632658" y="0">s</tspan>
				<tspan style="font-size: 12.55px; " x="13.946383" y="0">n</tspan>
			</text>

			<text transform="matrix(1,0,0,-1,-26.97,63.31)">
				<tspan style="font-size: 12.55px; " x="0" y="0">→</tspan>
			</text>

			<text transform="matrix(1,0,0,-1,-13.25,63.31)">
				<tspan style="font-size: 12.55px; " x="0" y="0">L</tspan>
				<tspan style="font-size: 12.55px; " x="7.2054219" y="0">y</tspan>
				<tspan style="font-size: 12.55px; " x="13.318733" y="0">s</tspan>
			</text>

			<text transform="matrix(1,0,0,-1,-61.84,47.21)">
				<tspan style="font-size: 12.55px; " x="0" y="0">𝟐</tspan>
			</text>

			<text transform="matrix(1,0,0,-1,5.45,54.12)">
				<tspan style="font-size: 17.93px; " x="0" y="0">𝛽</tspan>
			</text>

			<text transform="matrix(1,0,0,-1,15.45,61.39)">
				<tspan style="font-size: 12.55px; " x="0" y="0">𝟔</tspan>
				<tspan style="font-size: 12.55px; " x="6.2765002" y="0">𝟐</tspan>
			</text>

			<text transform="matrix(1,0,0,-1,28.01,61.39)">
				<tspan style="font-size: 12.55px; " x="0" y="0">A</tspan>
				<tspan style="font-size: 12.55px; " x="9.0632658" y="0">l</tspan>
				<tspan style="font-size: 12.55px; " x="12.553" y="0">a</tspan>
			</text>

			<text transform="matrix(1,0,0,-1,48.23,61.39)">
				<tspan style="font-size: 12.55px; " x="0" y="0">→</tspan>
			</text>

			<text transform="matrix(1,0,0,-1,61.94,61.39)">
				<tspan style="font-size: 12.55px; " x="0" y="0">P</tspan>
				<tspan style="font-size: 12.55px; " x="6.9920211" y="0">r</tspan>
				<tspan style="font-size: 12.55px; " x="11.109405" y="0">o</tspan>
			</text>

			<text transform="matrix(1,0,0,-1,15.45,47.86)">
				<tspan style="font-size: 12.55px; " x="0" y="0">𝟐</tspan>
			</text>

		</g>
	</g>
</svg>) 

Figure 8 | Structural and Functional Characterization of a New Double Variant Haemoglobin (HbG-Philadelphia/Duarte 
	
		
			
				𝛼
			

			
				𝟔
				𝟖
			

			
				A
				s
				n
			

			
				→
			

			
				L
				y
				s
			

			
				𝟐
			

			
				𝛽
			

			
				𝟔
				𝟐
			

			
				A
				l
				a
			

			
				→
			

			
				P
				r
				o
			

			
				𝟐
			

		
	
) 

International Scholarly Research Notices

Structural and Functional Characterization of a New Double Variant Haemoglobin (HbG-Philadelphia/Duarte 𝛼 𝟔 𝟖 A s n → L y s 𝟐 𝛽 𝟔 𝟐 A l a → P r o 𝟐 )

Figure 8

Structural and Functional Characterization of a New Double Variant Haemoglobin (HbG-Philadelphia/Duarte )