|
| Author | Study design | n | Joint replacement | Anaesthesia | Analgesia: study group | Control |
|
| Vendittoli et al. [14] | RCT | 42 | Knee | Spinal | LIA + PCA (275 mg ropivacaine, 30 mg ketorolac, adrenaline) plus 150 mg ropivacaine at 24 hrs | PCA |
| Kerr and Kohan [15] | Case series | 325 | Hip and Knee | Majority Spinal | LIA (max 300 mg ropivacaine, 30 mg ketorolac, adrenaline) plus reinjection at 15–20 hrs | N/A |
| Andersen et al. [16] | RCT | 40 | Hip | Spinal | LIA + PCA (300 mg ropivacaine, 30 mg ketorolac, adrenaline) plus reinjection next morning | PCA |
| Busch et al. [17] | RCT | 64 | Knee | General or regional | LIA + PCA (400 mg ropivacaine, 30 mg ketorolac, 5 mg epimorphine, adrenaline) | PCA |
| Essving et al. [18] | RCT | 48 | Knee | General | LIA + PCA (400 mg ropivacaine, 30 mg ketorolac, adrenaline) plus reinjection at 21 hrs | PCA |
| Gómez-Cardero and Rodríguez-Merchán [19] | RCT | 50 | Knee | Spinal | LIA (continuous intra-articular infusion 300 mls of 0.2% ropivacaine at 5 ml/hr until empty) | Saline infusion |
| Krenzel et al. [20] | RCT | 66 | Knee | Spinal | CFNB + posterior capsule injection + PCA (20 ml 0.2% ropivacaine) | CFNB + PCA |
| Andersen et al. [21] | RCT | 12 | Knee (bilateral) | Spinal | LIA + PCA (340 mg ropivacaine, adrenaline) plus reinjection at 8 and 24 hrs | PCA |
| Zhang et al. [22] | RCT | 80 | Knee | General | LIA (300 mg ropivacaine, 30 mg ketorolac, adrenaline) plus 48 hrs continuous infusion (ropivacaine, ketorolac) | Control 1: LIA (300 mg ropivacaine, 30 mg ketorolac, adrenaline) plus saline infusion Control 2: saline infusion |
| Chen et al. [23] | RCT | 92 | Hip | General | LIA + PCA (24 mls 0.5% bupivacaine) plus continuous infusion 2 ml/hr | PCA |
| Andersen et al. [24] | RCT | 16 | Knee (bilateral) | Spinal | LIA + PCA (300 mg ropivacaine, adrenaline) plus reinjection 24 hrs | PCA |
| Andersen et al. [25] | RCT | 32 | Knee | Spinal | LIA (170 mls 0.2% ropivacaine and adrenaline) + intra- and extra-articular injection ropivacaine and adrenaline at 24 hrs | LIA (170 mls 0.2% ropivacaine and adrenaline) + intra-articular injection ropivacaine and adrenaline only at 24 hrs |
| Spreng et al. [26] | RCT | 102 | Knee | Spinal | LIA + PCA (150 mg ropivacaine and adrenaline), subgroup with 30 mg ketorolac and 5 mg morphine Reinjection 24 hrs | Epidural + PCA |
| Andersen et al. [27] | RCT | 80 | Hip | Spinal | LIA (200 mg ropivacaine, 30 mg ketorolac, adrenaline) plus intra-articular injection at 8 hrs | Epidural |
| Andersen et al. [28] | RCT | 40 | Knee | Spinal | LIA + PCA (300 mg ropivacaine, 30 mg ketorolac, adrenaline) plus continuous intra-articular infusion (ropivacaine, ketorolac) | Epidural + PCA |
| Thorsell et al. [29] | RCT | 85 | Knee | Spinal or epidural | LIA (300 mg ropivacaine, 30 mg ketorolac, adrenaline) plus further injection day 1 (bupivacaine-adrenaline) | Epidural |
| Toftdahl et al. [30] | RCT | 80 | Knee | Spinal | LIA (300 mg ropivacaine, 30 mg ketorolac, adrenaline) plus intra-articular injection at 10 pm and 10 am | CFNB |
| Carli et al. [31] | RCT | 40 | Knee | Spinal | LIA + PCA (300 mg ropivacaine, 45 mg ketorolac, adrenaline) plus intra-articular injectionat 24 hrs | CFNB + PCA |
| Affas et al. [32] | RCT | 40 | Knee | Spinal | LIA + PCA (300 mg ropivacaine, 30 mg ketorolac, adrenaline) plus intra-articular infusion at 24 hrs | FNB + PCA |
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