Table of Contents
ISRN Endocrinology
Volume 2011, Article ID 768637, 7 pages
Research Article

Short-Term Calorie Restriction in Early Life Attenuates the Development of Proteinuria but Not Glucose Intolerance in Type 2 Diabetic OLETF Rats

1Department of Pharmacology, Faculty of Medicine, Kagawa University, Kagawa 761-0793, Japan
2Department of Gastroenterology, Faculty of Medicine, Kagawa University, Kagawa 761-0793, Japan

Received 5 August 2011; Accepted 5 September 2011

Academic Editors: B. A. Eghan and A. Saxe

Copyright © 2011 Daisuke Nakano et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Childhood obesity is becoming more prevalent; however, the influence of obesity or dieting during childhood on outcomes in adulthood is poorly understood. The aim of this study was to examine the effects of short-term calorie restriction (CR) and high-calorie feeding with high-fat or high-sucrose diets during early life on the development of glucose tolerance and diabetic nephropathy in later life of Otsuka Long-Evans Tokushima fatty (OLETF) rats. Neither high-calorie intake nor CR at 7–13 weeks of age affected glucose tolerance of 27-week-old OLETF rats. On the other hand, proteinuria was lower at 27 weeks of age in CR rats than in the other rats. These results suggest that short-term CR at a young age protects against the development of renal injury in later life. In contrast, short-term high-calorie intake or CR at a young age does not appear to affect glucose metabolism in later life.