Short-Term Calorie Restriction in Early Life Attenuates the Development of Proteinuria but Not Glucose Intolerance in Type 2 Diabetic OLETF Rats
Figure 1
Changes in plasma glucose levels during oral glucose tolerance tests performed at 13 (a) and 27 (b) weeks of age, and the calculated total areas under the glucose curves at 13 (c) and at 27 (d) weeks of age. Compared with the control LETO rats, the normal diet-fed, high-sucrose-fed, and high-fat-fed OLETF rats showed higher glucose levels following the oral glucose load at 13 weeks of age. The changes in blood glucose levels following the oral glucose load in calorie-restricted OLETF rats were almost identical to those in LETO rats at 13 weeks of age. Blood glucose levels were significantly greater in all OLETF rats than in LETO rats, and there were no differences in blood glucose level between any of the OLETF rats at 27 weeks of age. L: LETO + normal diet; O: OLETF + normal diet; HS: OLETF + high-sucrose diet; HF: OLETF + high-fat diet; CR: OLETF + calorie restriction. versus LETO rats, versus normal diet-fed OLETF rats.
