TY - JOUR
A2 - Parkar, M. H.
A2 - Walters, J.
A2 - Grenier, D.
AU - Segovia, Marcela
AU - Reina, Silvia
AU - Borda, Enri
AU - Sterin-Borda, Leonor
PY - 2011
DA - 2011/09/07
TI - Autoantibodies to the -Adrenoceptor from Patients with Periodontitis as a Risk Factor for Cardiac Dysfunction
SP - 791393
VL - 2011
AB - The presence of serum autoantibodies in periodontitis (P) patients against β1-adrenoceptor (β1-AR), using cardiac membranes or a synthetic β1-AR peptide corresponding to the second extracellular loop of human β1-AR as antigens, permit us to detect circulating antibody from 40 P patients but not in 20 normal individuals (control). Simultaneously, the P patients exhibited a decrease in HRV. Anti-β1-AR IgG titters correlated with the decrease in HRV of the same patients and the anti-β1-AR peptide IgG displayed partial agonist-like activity and modified the contractility of isolated atria, produced cyclic nucleotides, and inhibited the β1-AR agonistic activity of isoproterenol. We demonstrated in this study an association between periodontitis infection and an increased risk of cardiac disease, thereby highlighting the role of anti-β1-AR autoantibodies in alteration of myocardial contractility.
SN - null
UR - https://doi.org/10.5402/2011/791393
DO - 10.5402/2011/791393
JF - ISRN Dentistry
PB - International Scholarly Research Network
KW -
ER -