TY - JOUR A2 - Parkar, M. H. A2 - Walters, J. A2 - Grenier, D. AU - Segovia, Marcela AU - Reina, Silvia AU - Borda, Enri AU - Sterin-Borda, Leonor PY - 2011 DA - 2011/09/07 TI - Autoantibodies to the 𝜷 𝟏 -Adrenoceptor from Patients with Periodontitis as a Risk Factor for Cardiac Dysfunction SP - 791393 VL - 2011 AB - The presence of serum autoantibodies in periodontitis (P) patients against β1-adrenoceptor (β1-AR), using cardiac membranes or a synthetic β1-AR peptide corresponding to the second extracellular loop of human β1-AR as antigens, permit us to detect circulating antibody from 40 P patients but not in 20 normal individuals (control). Simultaneously, the P patients exhibited a decrease in HRV. Anti-β1-AR IgG titters correlated with the decrease in HRV of the same patients and the anti-β1-AR peptide IgG displayed partial agonist-like activity and modified the contractility of isolated atria, produced cyclic nucleotides, and inhibited the β1-AR agonistic activity of isoproterenol. We demonstrated in this study an association between periodontitis infection and an increased risk of cardiac disease, thereby highlighting the role of anti-β1-AR autoantibodies in alteration of myocardial contractility. SN - null UR - https://doi.org/10.5402/2011/791393 DO - 10.5402/2011/791393 JF - ISRN Dentistry PB - International Scholarly Research Network KW - ER -