Autoantibodies to the -Adrenoceptor from Patients with Periodontitis as a Risk Factor for Cardiac Dysfunction
Figure 3
Effect of increasing concentrations of anti-β 1-AR peptide IgG (IgG) on contractility (dF/dt) and production of cAMP and cGMP in isolated atria from rats. (a) Comparative effects of anti-β 1-AR peptide IgG on dF/dt (•-•) and on cAMP production (○-○). (b) Comparative effects of anti-β 1-AR peptide IgG on dF/dt (•-•) and on cGMP production (○-○). (c) Positive correlation between cAMP and dF/dt (corresponding data to A values). (d) Negative correlation between cGMP and dF/dt (corresponding data to B values). Values are mean ± s.e.m. of 20 patients with periodontitis.
