Solubility and Dissolution Enhancement of Etoricoxib by Solid Dispersion Technique Using Sugar Carriers

Table 1

Percent yield and percent drug content of etoricoxib solid dispersions.

Solid dispersion type	Ratio	Percent yield (%)^$	Percent drug content (%)^$
Etoricoxib : lactose	1 : 1	88.13 ± 7.53	96.68 ± 1.99
	1 : 5	91.18 ± 3.19	98.39 ± 2.42
Etoricoxib : sucrose	1 : 1	85.43 ± 2.43	97.94 ± 2.50
	1 : 5	89.63 ± 3.62	98.60 ± 2.13
Etoricoxib : mannitol	1 : 1	83.09 ± 2.13	95.75 ± 2.91
	1 : 5	86.51 ± 2.15	97.32 ± 0.85

^$Mean ± SD, n = 3.