Solubility and Dissolution Enhancement of Etoricoxib by Solid Dispersion Technique Using Sugar Carriers

Table 3

Correlation coefficient (R²) values in the analysis of dissolution data of etoricoxib solid dispersions using sugars.

Mathematical models	Formulation codes*
	SD-L (1 : 1)	SD-L (1 : 5)	SD-S (1 : 1)	SD-S (1 : 5)	SD-M (1 : 1)	SD-M (1 : 5)
Zero-order model	0.9462	0.9681	0.9276	0.9389	0.9276	0.9502
First-order model	0.9846	0.9871	0.9599	0.9689	0.9718	0.9807
Higuchi model	0.9892	0.9852	0.9756	0.9782	0.9714	0.9824
Hixson-Crowell model	0.9943	0.9958	0.9886	0.9882	0.9837	0.9897
Korsmeyer-Peppas model	0.9870	0.9807	0.9754	0.9718	0.9728	0.9739

* Formulation codes:
SD-L (1 : 1), and SD-L (1 : 5): etoricoxib solid dispersions using lactose
SD-S (1 : 1), and SD-S (1 : 5): etoricoxib solid dispersions using sucrose
SD-M (1 : 1), and SD-M (1 : 5): etoricoxib solid dispersions using mannitol.