Table of Contents
ISRN Pharmaceutics
Volume 2011, Article ID 821874, 3 pages
http://dx.doi.org/10.5402/2011/821874
Research Article

Study on HIF-1α Gene Translation in Psoriatic Epidermis with the Topical Treatment of Capsaicin Ointment

Department of Dermatology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China

Received 30 March 2011; Accepted 2 May 2011

Academic Editors: M. AghazadehTabrizi and A. G. Oliveira

Copyright © 2011 Chun-shui Yu. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective. To investigate the mechanism of capsaicin in treating active psoriasis vulgaris. Methods. HIF-1α gene translation in active psoriatic lesions before and after 21-day treatment with capsaicin ointment was detected by in situ hybridization. Results. There was positive staining of HIF-1α gene in all the layers of psoriatic epidermis (100.0%) before the treatment with capsaicin ointment, but the dyeing in epidermis were reduced obviously (22.2%) after the treatment for 21 days. Conclusion. HIF-1α gene translation in psoriatic epidermis was downregulated after capsaicin treatment for 21 days.