Carcinomas of Distal Fallopian Tube and Their Association with Tubal Intraepithelial Carcinoma: Do They Share a Common “Precursor” Lesion? Loss of Heterozygosity and Immunohistochemical Analysis Using PAX 2, WT-1, and P53 Markers

Table 4

Immunohistochemical (IHC) and loss of heterozygosity (LOH) analysis of Group 2: primary peritoneal serous carcinomas (PPSC) without associated tubal intraepithelial carcinoma (TIC).

PPSC/−	PAX 2		WT-1		P53
	* IHC (CS)	LOH	*IHC (CS)	LOH	* IHC (CS)	LOH
Case 1	7	LOH	7	No LOH	7	No LOH
Case 2	**0	LOH	7	LOH	7	No LOH
Case 3	**0	LOH	7	No LOH	7	No LOH
Case 4	7	LOH	7	LOH	7	LOH
Case 5	**0	LOH	7	No LOH	7	No LOH
Case 6	7	No LOH	7	LOH	3	LOH
Case 7	3	LOH	7	LOH	7	LOH
Case 8	3	No LOH	7	No LOH	7	No LOH
Case 9	3	LOH	7	No LOH	7	LOH

* IHC (CS): a cumulative score (CS) was calculated incorporating PS as well as IS. The score was derived by the summation of PS and IS, ranged from 0 to 8 and is further divided into Negative (0), Weak (1-2), Moderate (3–5), Strong (6–8).
(**): PAX signature.