Ex Vivo Evaluation of Insulin Nanoparticles Using Chitosan and Arabic Gum

Table 2

Three types of selected insulin nanoparticles based on 2³ factorial design experiment. 𝑥₁, 𝑥₂, and 𝑥₃ are chitosan concentration (mg/mL), Arabic gum concentration (mg/mL) and insulin amount (mg) respectively, and association efficiency (run in triplicate) was selected as the dependent variable (𝑦).

Formulation code	𝑥1	𝑥2	𝑥3	𝑦% (mean ± sd) (𝑛=3)
F1	10	1	5	31.2±2.83
F2	10	5	5	35.8±4.31
F3	10	5	10	37.5±2.75