Table of Contents
ISRN Endocrinology
Volume 2011, Article ID 869273, 6 pages
Research Article

Evaluation of Antihyperglycemic Activity of Citrus limetta Fruit Peel in Streptozotocin-Induced Diabetic Rats

1Department of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal 700032, India
2Guru Nanak Institute of Pharmaceutical Science and Technology, Panihati, Kolkata, West Bengal 700114, India
3Pharmacognosy Division, Bengal School of Technology, Sugandha, Hooghly, West Bengal 712102, India

Received 9 April 2011; Accepted 20 May 2011

Academic Editors: C. Anderwald and T.-H. Tung

Copyright © 2011 Sriparna KunduSen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The present paper aims to evaluate antihyperglycemic activity of methanol extract of Citrus limetta fruit peel (MECL) in streptozotocin-induced (STZ; 65 mg/kg b.w.) diabetic rats. Three days after STZ induction, diabetic rats received MECL orally at 200 and 400 mg kg−1 body weight daily for 15 days. Glibenclamide (0.5 mg kg−1 p. o.) was used as reference drug. Blood glucose levels were measured on 0th, 4th, 8th, and 15th days of study. Serum biochemical parameters namely, SGOT, SGPT and ALP were estimated. The TBARS and GSH levels of pancreas, kidney, and liver were determined. MECL significantly ( 𝑃 < 0 . 0 0 1 ) and dose dependently normalized blood glucose levels and serum biochemical parameters, decreased lipid peroxidation, and recovered GSH as compared to those of STZ control. The present paper infers that in STZ-induced diabetic Wistar rats, C. limetta fruit peel demonstrated a potential antihyperglycemic effect which may be attributed to its antioxidant property.