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Research Article

Evaluation of Antihyperglycemic Activity of Citrus limetta Fruit Peel in Streptozotocin-Induced Diabetic Rats

Table 3

Effect of different doses of MECL on blood sugar level of normal and hyperglycaemic rats.
Group DoseBlood glucose level mg/dL
0th day4th day8th day15th day
Saline control5 mL/kg (p.o.) 7 9 . 6 2 ± 4 . 4 7 8 . 2 3 ± 4 . 2 7 8 . 1 6 ± 2 . 4 7 8 . 1 2 ± 3 . 1
STZ control65 mg/kg (i.p.) 2 6 7 . 8 ± 1 2 . 3 * 2 8 8 . 7 ± 1 5 . 6 * 2 8 7 . 3 ± 6 . 3 * 2 9 4 . 8 ± 2 . 8 *
STZ + MECL200 mg/kg (p.o.) 2 6 6 . 5 ± 4 . 6 ** 1 0 0 . 6 ± 4 . 4 ** 7 4 . 9 ± 5 . 8 ** 7 4 . 2 ± 2 . 7 **
STZ + MECL400 mg/kg (p.o.) 2 4 6 . 2 ± 3 . 2 ** 9 3 . 8 ± 2 . 9 ** 8 1 . 4 2 ± 2 . 7 ** 7 9 . 3 ± 3 . 0 2 **
STZ + Glibenclamide0.5 mg/kg (p.o.) 2 8 1 . 2 ± 0 . 3 ** 9 6 . 3 ± 4 . 6 ** 7 7 . 8 3 ± 6 . 9 ** 7 4 . 7 ± 1 . 7 **
Values are expressed as mean ± SEM ( 𝑛 = 6 ); * 𝑃 < 0 . 0 0 1 compared with saline control group and ** 𝑃 < 0 . 0 0 1 compared with STZ-control group.