Research Article

Evaluation of Antihyperglycemic Activity of Citrus limetta Fruit Peel in Streptozotocin-Induced Diabetic Rats

Table 5

Effect on different serum enzyme levels of different doses of MECL in normal and hyperglycaemic rats.

GroupDoseSGOT (IU/L)SGPT (IU/L)ALP (KA units)

Saline control5 mL/kg (p.o.) 1 3 0 . 5 ± 1 . 3 9 7 . 9 6 ± 0 . 1 5 2 8 . 3 3 ± 1 . 7 6
STZ control65 mg/kg (i.p.) 2 4 2 . 6 ± 1 . 2 1 * 2 0 6 . 7 ± 0 . 1 4 * 7 3 . 0 1 ± 1 . 8 1 *
STZ + MECL200 mg/kg (p.o.) 1 7 7 . 0 4 ± 0 . 8 ** 1 3 1 . 3 ± 0 . 1 4 ** 4 7 . 3 ± 1 . 2 **
STZ + MECL400 mg/kg (p.o.) 1 5 8 . 7 9 ± 0 . 8 4 ** 1 2 5 . 7 4 ± 0 . 7 3 ** 4 3 . 2 ± 2 . 4 **
STZ + Glibenclamide0.5 mg/kg (p.o.) 1 4 3 . 3 8 ± 2 . 2 6 ** 1 1 9 . 5 ± 1 . 2 2 ** 3 7 . 2 1 ± 1 . 6 5 **

Values are expressed as mean ± SEM ( 𝑛 = 6 ); * 𝑃 < 0 . 0 0 1 compared with saline control group and ** 𝑃 < 0 . 0 0 1 compared with STZ-control group.