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ISRN Vascular Medicine
Volume 2011 (2011), Article ID 876864, 8 pages
Research Article

Heart Rate Variability in HIV Patients, Diabetics, and Controls: The AGATAA Study

1School of Medicine, University of São Paulo, Sao Paulo, SP, Brazil
2Hospital Universitario, University of São Paulo, Sao Paulo, SP, Brazil
3Instituto de Infectologia Emílio Ribas, São Paulo, SP, Brazil
4Federal University of Espírito Santo, Vitória, ES, Brazil

Received 31 March 2011; Accepted 21 May 2011

Academic Editors: B. Hambly and P. Schoenhagen

Copyright © 2011 Isabela M. Benseñor et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


HIV infection can affect cardiac autonomic function. We aimed to compare heart rate variability in 29 HIV-infected patients using highly active antiretroviral therapy (HAART), 28 naïve-treatment HIV patients, and diabetics with controls. There was no difference in time index parameters among groups. The normalized power of the low-frequency component (LF) in naïve patients of 39.9 (interquartile interval (IQ), 28.5–65.7) and diabetics of 42.9 (IQ, 14.5–57.7) were decreased compared with controls (67.5, IQ, 37.9–75.4). The normalized power of the high-frequency component (HF) in naïves of 49.7 (IQ, 30.4–64.8), and diabetics of 53.1 (IQ, 34.5–72.2) were increased compared with controls (27.0, IQ, 19.0–57.3). Naïve and diabetics also presented with lower LF/HF ratios (0.8 (IQ, 0.6–2.3), and 0.9 (IQ, 0.3–1.4),) compared with controls (2.3 (IQ, 0.8–3.3)). We can speculate that HAART improves autonomic imbalance in frequency domain indices because there was no difference between the HAART group and controls.