Table of Contents
ISRN Surgery
Volume 2011, Article ID 902971, 3 pages
http://dx.doi.org/10.5402/2011/902971
Case Report

Diffuse Cutaneous Metastases as the Only Sign of Extranodal Tumor Spread in a Patient with Adenocarcinoma of the Colon

Department of Surgery, University of Siena, Policlinico le Scotte, Viale Bracci, 53100 Siena, Italy

Received 23 February 2011; Accepted 25 April 2011

Academic Editors: A. H. Al-Salem and D. M. Bolton

Copyright © 2011 Serenella Civitelli et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Cutaneous metastases from large bowel cancer are uncommon and are usually associated with organ involvement. Localization of lesions to the skin is mainly attributed to vascular and anatomical relationship, since most of them are seen in the abdominal wall or in a surgical scar. We report a 73-year-old woman in whom metastatic nodules from a poorly differentiated adenocarcinoma of the right colon developed throughout the skin (buttock, trunk, chest wall, arms, and neck) and remained the only sign of extranodal tumor spread until patient's death, seven months later. This unusual behaviour suggests that localization of neoplastic cells to the skin may be a site-specific process, determined by adhesion molecules and/or by growth factors found at that site.