Table of Contents
ISRN Oncology
Volume 2011, Article ID 915925, 9 pages
Review Article

Papillary Thyroid Carcinoma: Differential Diagnosis and Prognostic Values of Its Different Variants: Review of the Literature

1Universidad Autónoma Metropolitana, México City, Mexico
2School of Dentistry, Research Department, Universidad Juárez del Estado de Durango (UJED), Durango, Mexico
3Health Care Department, Universidad Autónoma Metropolitana, Xochimilco, Mexico City, Mexico
4Instituto Nacional de Oncología y Radiobiología (INOR), La Habana 10400, Cuba

Received 13 August 2011; Accepted 7 September 2011

Academic Editors: C. Piazza and A. H. Wolfson

Copyright © 2011 Rogelio Gonzalez-Gonzalez et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Papillary thyroid carcinoma is the most common thyroid malignancy, and has an excellent prognosis, even with cervical lymph node metastasis; however, histological variants are considered relevant, which may be associated with familial adenomatous polyposis and tumor aggressiveness. Histological features, such as vascular and/or lymphatic invasion, angiogenesis, multifocality, high cellular proliferation rate, neoplastic cell dissemination, and the histological varieties, are indicative of poor prognosis, together with associated clinical factors: age, sex, and tumor size.