Table of Contents
ISRN Obstetrics and Gynecology
Volume 2011, Article ID 928592, 5 pages
Clinical Study

Evaluating the Association between Assisted Conception and the Severity of Preeclampsia

1Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, 101 Manning Drive, Chapel Hill, NC 27599-7570, USA
2Department of Obstetrics and Gynecology, The Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA

Received 9 August 2011; Accepted 7 September 2011

Academic Editors: R. Jones and S. San Martin

Copyright Β© 2011 Kathryn C. Calhoun et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. To investigate the association between assisted conceptions and preeclampsia (PEC), including assessment of severity of disease. Methods. In a prospective case control study, cases were selected from women with preeclampsia and controls from women without preeclampsia. Exposure was defined as assisted conception with intrauterine insemination or in vitro fertilization (IUI or IVF). We assessed the association between exposure and outcome, using Chi square or Fisher's exact tests. Stratified analyses and multivariable logistic regression were used to control for confounders. Results. Preeclampsia was associated with assisted conception after controlling for age and race (AOR 2.2, [1.03–4.72]). All women with preeclampsia who had assisted conceptions demonstrated severe disease and were more likely to have abnormal lab values: AST >45 (AOR = 6.01 [1.63–22.21] 𝑃 = 0 . 0 0 7 ), creatinine ≥1 (AOR 2.92 [0.82–10.4], 𝑃 = 0 . 0 9 ) or platelets <100 (AOR 5.74 [1.00–32.76] 𝑃 = 0 . 0 4 9 ), after adjusting for race, age, and multiple gestations. Conclusion. Assisted conceptions are associated with a more severe preeclamptic phenotype.