Glycogen as a Putative Target for Diagnosis and Therapy in Brain Pathologies
Figure 11
MSO effects on glycogen content determined on mouse cerebral cortex of various mice. (a): Various parental inbreed mouse strains are sacrificed 8 hours after receiving a single MSO dose (75 mg/kg). Variation in cerebral cortex induced by MSO was determined as percentage of glycogen increase observed 8 h after MSO administration and vehicle for the eight parental strains, . (b): MSO-Fast and MSO-Slow from G6 were given a single MSO dose (75 mg/kg) and were sacrificed either at various times after dosing or at the onset of seizures (Seiz). Significance was given for the total variation of brain glycogen content between the two lines and for value of MSO-Slow mice at the onset of seizures compared to before and after seizures. < 0.05, < 0.001. Values are expressed as mean ± SEM of at least 20 mice, and statistical analysis was made using Student test for (a) and using ANOVA test for (b). Data adapted from Cloix et al. [112].
