Table of Contents
ISRN Vascular Medicine
Volume 2011, Article ID 936974, 6 pages
Research Article

Development of a Standardized Clinical Protocol for Ranking Foods and Meals Based on Postprandial Triglyceride Responses: The Lipemic Index

1Department of Human Health and Nutritional Science, University of Guelph, Guelph, ON, N1G2W1, Canada
2Clinical Trials Division, Nutrasource Diagnostics Inc., Guelph, ON, Canada N1G 0B4

Received 13 July 2011; Accepted 15 August 2011

Academic Editor: A. Csaszar

Copyright © 2011 Erin M. O'Reilly et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Postprandial triglyceride levels are being increasingly recognized as an independent risk factor for the development of cardiovascular disease (CVD). There is a need for developing a standardized clinical protocol which allows foods and meals to be ranked based on the resulting postprandial triglyceride response. This pilot study offers a novel approach to standardize such testing based on equicaloric intakes, allowing for increased flexibility in comparing different food and meal offerings, as well as a high potential for public knowledge transfer. Our laboratory has developed a standardized 2100 kJ beverage, consisting of fat, protein, and simple carbohydrates (LIXR) with the goal of eliciting a reference postprandial triglyceride response. As we hypothesized, a certain commercial product which gave favourable glycemic responses yielded significantly higher triglyceride responses than our reference solution, indicating an important gap in current methods of identifying low-risk foods for subjects at risk for CVD. The lipemic index may eventually be used in combination with other nutritional tools to provide an enhanced overall assessment of health risks associated with consuming certain foods.