Review Article

Potential Agents against Plasma Leakage

Figure 3

The role of Rho GTPases and sphingosine 1phosphate in barrier maintenance. Prolea = proleakage mediators, VEGF = VEGF-165 (the predominant isoform of VEGF A), GIT 1 = G protein-coupled receptor kinase interactor-1, Pix = p21-activated kinase-interacting exchange factor, FAK = focal adhesion kinase, SFK = Src family kinase, S1P = sphingosine 1phosphate, S1PR = sphingosine 1phosphate receptor, Cdc = Cdc42, Rho = RhoA, α = α catenin, β = β catenin, Sc = Scar, WASP = Wiskott-Aldrich syndrome protein, Arp = Arp2/3, PAK = p21-activated kinase, MCLK = myosin light chain kinase, Barrier str = barrier strengthening, Barrier disr = barrier disruption, solid line = contributing factor, and dashed line = inhibiting factor. The various Rho GTPases and S1P have dual role in barrier maintenance.
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