Research Article
Altered or Impaired Immune Response to Hepatitis B Vaccine in WNIN/GR-Ob Rat: An Obese Rat Model with Impaired Glucose Tolerance
Table 1
Spleen weight, lymphocyte subsets, lymphocyte proliferative response, and serum IgG and IgM levels in 3-month-old WNIN/GR-Ob lean and obese rats.
| Immune parameters | 3 month old WNIN/GR-Ob females | Lean | Obese |
| Spleen weight (mg)/g body weight | 2 ± 0.07* | 1.3 ± 0.05 | Total T cells (%) | 43.9 ± 1.64* | 37.0 ± 1.92 | T helper cells (%) | 38.1 ± 1.58* | 29.1 ± 1.8 | T cytotoxic cells (%) | 14.7 ± 0.9 | 16.8 ± 0.48 | Total B cells (%) | 29.5 ± 3.22 | 23.4 ± 1.01 | Splenic lymphocyte proliferative response (T/C) | 11.6 ± 1.95 | 7.9 ± 1.85 | IgG levels (mg/mL) | 2.02 ± 0.184* | 3.01 ± 0.38 | IgM levels (μg/mL) | 16.7 ± 1.24* | 27.7 ± 2.46 |
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Values are in mean ± SE; * (significant difference between lean and obese rats).
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