Table of Contents
ISRN Pharmaceutics
Volume 2011, Article ID 981254, 7 pages
http://dx.doi.org/10.5402/2011/981254
Clinical Study

Randomized, Double-Blind, and Placebo-Controlled Trial of Clenbuterol in Denervated Muscle Atrophy

1Department of Hand Surgery, Huashan Hospital of Fudan University, Shanghai 200040, China
2Clinical Development, Neurology & Pain, R&D, Allergan Inc., 2525 Dupont Dr., Irvine, CA 92612, USA

Received 1 June 2011; Accepted 21 June 2011

Academic Editors: M. Cabeza and J. K. Lalla

Copyright © 2011 Guang-Liang Jiang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objectives. 𝛽 2 -adrenergic agonists, such as clenbuterol, have been shown to promote the hypertrophy of healthy skeletal muscles and to ameliorate muscle wasting in a few pathological conditions in both animals and humans. We intended to investigate the clinical efficacy of clenbuterol on attenuating denervation-induced muscle atrophy. Methods. A double-blind, placebo-controlled, parallel, and randomized trial was employed. 71 patients, suffering from brachial plexus injuries, were given either clenbuterol (60 μg, bid) or placebo for 3 months. Before and at the end of the study, patients were given physical examinations, biopsies of biceps brachii, electromyograms (EMGs), and other laboratory tests. Results. Compared with placebo treatment, clenbuterol significantly mitigated the decreases in cross-sectional areas of type I and II muscle fibers and alleviated the reduction in fibrillation potential amplitudes, without any adverse effects. Conclusions. Clenbuterol safely ameliorated denervated muscle atrophy in this cohort; thus larger clinical studies are encouraged for this or other 𝛽 2 agonists on denervation-induced muscle atrophy.