Table of Contents
ISRN Materials Science
Volume 2012, Article ID 106484, 6 pages
Research Article

Development of Piezoelectric Ultrasonic Thrombolysis Device for Blood Clot Emulsification

1Division of Materials Technology, School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798
2Lee Kong Chian School of Medicine, Nanyang Technological University, 50 Nanyang Drive, Singapore 637553
3National University Heart Centre, National University of Singapore, 5 Lower Kent Ridge Road, Singapore 119074
4National University Health System, National University of Singapore, 1E, Kent Ridge Road, Singapore 119228

Received 15 February 2012; Accepted 13 March 2012

Academic Editors: M. Martino and Y. Zhou

Copyright © 2012 Tao Li et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Ultrasonic thrombolysis is an effective method to treat blood clot thrombus in a blood vessel. This paper reports an OD 5 mm and an OD 10 mm piezoelectric thrombolysis transducers that vibrate longitudinally and generate a pressure field at the distal vibration tip. Studies of vibration mode, pressure field pattern, and cavitation effect were carried out. The transducers were also tested for blood clot emulsification. The results indicate both transducers are effective. The OD 10 mm transducer with a long transmission wire has shown to provide a strong cavitation effect and work effectively at low frequency, high amplitude, and high power conditions. The OD 5 mm transducer was found to operate effectively under higher frequency, low amplitude, and lower power conditions. The cavitation effect is moderate, which facilitates precision and controls over obtaining a more uniform emulsification result.