Table of Contents
ISRN Public Health
Volume 2012 (2012), Article ID 121697, 7 pages
Clinical Study

The Effects of Two Maternal Vitamin A Supplementation Regimens on Serum Retinol in Postpartum Mothers: A Randomised Controlled Trial in Brazil

1Diretoria de Pesquisas, Instituto de Medicina Integral Professor Fernando Figueira, Caixa Postal 1393, 50070-550 Recife, PE, Brazil
2Departamento de Nutrição, Centro de Ciências da Saúde, Universidade Federal de Pernambuco (UFPE), 50670-901 Recife, PE, Brazil
3Rua Joaquim Marques de Jesus, 86, apto 101, Piedade, 54420-240 Jaboatão dos Guararapes, PE, Brazil

Received 9 July 2012; Accepted 26 July 2012

Academic Editors: S. M. Ahmed and A. R. Mawson

Copyright © 2012 Luciana Marques Andreto et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. To test whether the serum retinol level in mothers supplemented with 400,000 IU of vitamin A is higher than in those supplemented with 200,000 IU and to estimate duration of the protective effect of vitamin A supplementation in the serum retinol level. Methods. Double-blind, randomised controlled trial performed in two hospitals in the state of Pernambuco in northeast Brazil. Three hundred twelve mothers were recruited immediately postpartum. All women received a capsule containing 200,000 IU of vitamin A, and 10 days after delivery, they were randomly assigned to one of two treatment groups. One group received a second capsule containing vitamin A and the other group received a placebo. Each group was invited back after 2, 4, and 6 months for serum retinol analyses. Results. No difference was found between the two groups in serum maternal retinol concentration at 2 months (2.13 versus 2.03 μmol/L), 4 months (2.20 versus 2.24 μmol/L) or 6 months (2.29 versus 2.31 μmol/L). Because there was no further effect and because this population has a level of vitamin A deficiency considered mild, our results do not support a proposal to increase the dosing schedule for vitamin A in postpartum women as recommended by the IVACG.