Assessing the Impact of Increasing Antimicrobial Resistance of Vibrio cholerae on the Future Trends of Cholera Epidemic

Table 1

Model parameters and their interpretations.

Parameter definition	Symbol	Units	Point estimate	Range	Source
Recruitment rate	Λ	People/year	100 000	—	[15]
Bacteria death rate	𝜔	/day	0.033	0.03–0.033	[7, 8, 15]
Bacteria shedding rate	𝜙1	cells/mL day	30.0	10.0–50.0	[8, 15]
Bacteria shedding rate	𝜙2	cells/mL day	50.0	10.0–50.0	[8, 15]
Natural mortality rate	𝜇	/year	0.0142	0.0142–0.02	[15]
Bacteria ingestion rate	𝜗	/day	0.5	0.15–1.5	[8, 15]
Half saturation constant	𝐾1	cells/mL	10^7	10^6-10^9	[8, 15]
Half saturation constant	𝐾2	cells/mL	10^6	10^6-10^9	[8, 15]
Cholera related mortality rate	𝛿1	/year	0.0240	0.0240–0.4622	[8]
Cholera related mortality rate	𝛿2	/year	0.4622	0.0240–0.4622	[8]
Recovery rate for sensitive strain	𝑟1	/year	22.6	11.3–43.2	[8]
Recovery rate for resistant strain	𝑟2	/year	21.6	11.3–43.2	[8]
Proportion of infected individuals who develop drug resistance	𝑝	—	0.5	0.001–0.5	Assumed