Table of Contents
ISRN Pulmonology
Volume 2012, Article ID 138326, 7 pages
Clinical Study

Sex Differences in the Effects of Inhaled Corticosteroids on Weight Gain among Patients with Asthma

1Centre de Recherche, Hôpital du Sacré-Cœur de Montréal-A University of Montreal Affiliated Hospital, 5400 Boulevard Gouin West, Montreal, QC, Canada H4J 1C5
2Special Individualized Program, Concordia University, 7141 Sherbrooke Street West, Montreal, QC, Canada H4B 1R6
3Department of Exercise Science, Concordia University, 7141 Sherbrooke Street West, Montreal, QC, Canada H4B 1R6
4Montreal Behavioural Medicine Centre, Montreal, QC, Canada
5Département de Psychologie, Université du Québec à Montréal (UQAM), P.O. Box 8888, Succursale Centre-Ville, Montreal, QC, Canada H3C 3P8
6Research Centre, Montreal Heart Institute-A University of Montreal Affiliated Hospital, 3600 Rue Bélanger, Montreal, QC, Canada H1T 1C8

Received 1 August 2012; Accepted 16 August 2012

Academic Editors: A. M. Boylan, A. P. Comellas, A. Kurdowska, K. Nishimura, and C. C. Witt

Copyright © 2012 Amanda K. Rizk et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Studies have shown that asthma and asthma exacerbations are related to body weight and that this relationship might be sex-specific. While oral corticosteroids have been associated with weight gain, little is known about the effect of inhaled corticosteroid (ICS) use on short-term weight gain. The purpose of the present study was to examine whether ICSs would be associated with weight gain among asthmatic patients. Methods. A total of 180 adult patients with physician-diagnosed asthma provided details of their medical history and demographic information, along with height and weight at baseline and at one year. Weight change was defined as follow-up minus baseline weight. General linear models were used to assess the relationship between ICS dose (fluticasone propionate equivalent) and sex. Results. Significant main effects of sex ( 𝑃 = . 0 0 5 ) and ICS dose ( 𝑃 = . 0 3 6 ) and an interaction effect of sex and ICS dose ( 𝑃 = . 0 0 3 ) on weight change were observed. Further analysis of the interaction indicated that women had greater weight gain, while men had decreased weight with increased ICS dose. Conclusions. Findings suggest that ICSs may trigger weight gain in females and highlight the need for studies to confirm this relationship and examine the potential underlying mechanisms.